family with sequence similarity 27 member CGenealiases: FAM27A · FAM27A1 · FAM27A3 · bA7G23.5
Q-omics provides the consensus-scored FAM27C profile across patient tissues and cancer cell-line models. FAM27C expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, FAM27C is differentially expressed in 9, with the highest sampling consensus in KIRP. Additionally, FAM27C RNA expression shows 16,136 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LGG, KIRP, and UVM as cancer lineages where FAM27C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM27C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM27C survival associations across molecular data types. FAM27C RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM27C RNA expression–survival associations across cancer types. High FAM27C expression shows favorable associations in LGG, COAD, UCEC, MESO, THYM and READ. The LGG Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for FAM27C RNA expression.
This table summarizes FAM27C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for FAM27C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM27C shows lower tumor expression in BRCA, ESCA and UCEC and higher tumor expression in KIRP, KIRC and STAD. The KIRP box plot shows higher FAM27C RNA expression in tumor versus normal tissue (log2 FC = +0.214, t-test p < 0.001).
This table shows molecular features associated with FAM27C in patient tissues and cancer cell lines. In patient samples, FAM27C shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
