Across TCGA pan-cancer cohorts, FAM27C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM27C data layer.
The strongest signal is observed in brain lower grade glioma (LGG), where higher FAM27C RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM27C expression acts as an unfavorable survival marker, although some lineages such as LGG and COAD show a favorable association.
LGG, COAD, and UCEC are the cancer types where FAM27C RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.