Hematopoietic stem cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Hematopoietic stem cell proliferation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 35 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Hematopoietic stem cell proliferation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UVM, show the opposite pattern, with higher activity associated with better survival.

HNSC, ACC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.780	0.650	.001	82	view →
ACC	OS	Median	All	0.614	0.919	<.001	74	view →
UVM	DFS	Tertile	III,IV	0.876	0.377	.001	72	view →
KIRP	DFS	Quartile	All	0.511	0.612	.004	34	view →
THCA	DFS	Median	All	0.907	0.760	<.001	33	view →
COAD	OS	Median	All	0.451	0.654	<.001	28	view →
ESCA	OS	Median	II,III,IV	0.594	0.417	.009	21	view →
LGG	DFS	Quartile	All	0.206	0.448	<.001	20	view →
LIHC	OS	Tertile	All	0.610	0.763	.012	20	view →
CHOL	OS	Quartile	All	0.134	1.000	.010	13	view →
UCS	DFS	Tertile	All	0.132	0.426	.015	12	view →
CESC	OS	Median	IV	0.845	0.372	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0071425–HNSC (DFS)

Open the HNSC breakdown →