GO:0071397Ontology (GO BP)GO biological process · ~20 member genes
Q-omics provides the Cellular response to cholesterol (GO:0071397) pathway profile, scoring each patient from the combined activity of its roughly 20 member genes. Pathway activity is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 9, with the highest sampling consensus in KIRC. Additionally, pathway RNA activity shows 33,354 significant cross-omics associations, again with the highest sampling consensus in THCA. Together, these results highlight BLCA, KIRC, and THCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Cellular response to cholesterol survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Cellular response to cholesterol activity shows favorable associations in ESCA and SCLC, but unfavorable associations in BLCA, MESO, READ and CHOL. In the BLCA Kaplan–Meier curve the high-activity group declines faster, consistent with the unfavorable association (log-rank p = .003). BLCA ranks highest by sampling consensus for Cellular response to cholesterol.
This table summarizes Cellular response to cholesterol tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 9 cancer types, while mass-spec protein activity shows differences in 4. The strongest signals are in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across COAD and READ and lower tumor activity in KIRC, THCA, LIHC and BRCA. In the KIRC box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.043, t-test p < 0.001).
This table shows molecular features associated with Cellular response to cholesterol pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in THCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in CNS.
