Cellular response to cholesterol

Across TCGA patient cohorts, RNA activity of the Cellular response to cholesterol pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A_S667, MAP1A, and POSTN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cholesterol activity versus MAP1A_S667 in HNSC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAP1A_S667 →	+0.487	+0.056	.001	<.001	3	8
HNSC	MAP1A →	+0.411	+0.056	.001	<.001	3	7
OV	POSTN →	+1.261	+0.062	<.001	<.001	3	6
HNSC	UCHL1 →	+0.939	+0.047	<.001	<.001	3	6
CCRCC	EFEMP2 →	+0.729	+0.053	.002	<.001	3	6
CCRCC	LTBP2 →	+0.830	+0.046	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071397 vs MAP1A_S667 — HNSC

Explore this scatter interactively →