Cellular response to cholesterol

Across TCGA cell cohorts, RNA activity of the Cellular response to cholesterol pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Docetaxel, Gefitinib, and Navitoclax, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Docetaxel grouped by Cellular response to cholesterol-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Docetaxel →	+1.314	+1.371	.016	.008	1	1
KIDNEY	Gefitinib →	-0.955	-1.371	.033	.008	1	1
KIDNEY	Navitoclax →	+0.989	+1.371	.036	.008	1	1
KIDNEY	BI-2536 →	+0.825	+1.371	.039	.008	1	1
KIDNEY	Dyrk1b_0191 →	-0.645	-1.371	.017	.008	1	1
KIDNEY	Pevonedistat →	+1.245	+1.371	.016	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Docetaxel by Cellular response to cholesterol activity — KIDNEY

Explore this box plot interactively →