Cellular response to cholesterol

Across TCGA patient cohorts, RNA activity of the Cellular response to cholesterol pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A3, PDLIM3, and SMPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cholesterol activity versus COL5A3 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL5A3 →	+0.603	+0.507	.003	.001	3	4
LSCC	PDLIM3 →	+0.695	+0.442	<.001	.003	3	3
LSCC	SMPD1 →	+0.419	+0.428	.001	.008	3	3
UCEC	RRAD →	+1.119	+0.513	.002	<.001	3	3
LSCC	MRGPRF →	+0.290	+0.393	.007	.002	3	3
LSCC	RPL4P3 →	-0.247	-0.529	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071397 vs COL5A3 — BRCA

Explore this scatter interactively →