Error-free translesion synthesis

Across TCGA patient cohorts, RNA activity of the Error-free translesion synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM6, MCM2, and LIG1_S141, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Error-free translesion synthesis activity versus MCM6 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM6 →	+0.521	+0.059	<.001	<.001	3	8
UCEC	MCM2 →	+0.385	+0.050	<.001	.002	3	7
UCEC	LIG1_S141 →	+0.556	+0.088	.002	.001	3	7
UCEC	MCM5 →	+0.458	+0.057	<.001	.005	3	7
OV	MCM7 →	+0.398	+0.039	.004	.003	2	8
UCEC	MCM4 →	+0.396	+0.049	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070987 vs MCM6 — UCEC

Explore this scatter interactively →