Lens fiber cell differentiation

Across TCGA patient cohorts, RNA activity of the Lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP2, LTBP2, and CAVIN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell differentiation activity versus TIMP2 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.942	+0.237	<.001	<.001	3	8
BRCA	LTBP2 →	+1.018	+0.288	<.001	<.001	3	8
UCEC	CAVIN1 →	+0.941	+0.211	<.001	<.001	3	7
UCEC	SAMD4A →	+0.816	+0.257	.001	<.001	3	7
BRCA	PRRX1 →	+1.213	+0.284	<.001	<.001	3	7
UCEC	SPOCK1 →	+1.343	+0.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070306 vs TIMP2 — BRCA

Explore this scatter interactively →