Lens fiber cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Lens fiber cell differentiation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Lens fiber cell differentiation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and READ, show the opposite pattern, with higher activity associated with better survival.

MESO, LGG, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.701	0.460	.003	62	view →
LGG	DFS	Median	All	0.609	0.812	<.001	45	view →
STAD	DFS	Quartile	II,III,IV	0.506	0.830	.001	42	view →
READ	OS	Tertile	II,III,IV	0.806	0.418	.001	41	view →
LIHC	DFS	Tertile	III,IV	0.147	0.398	.002	34	view →
LAML	DFS	Quartile	All	0.594	0.260	.002	28	view →
ACC	OS	Quartile	All	0.402	0.793	<.001	28	view →
THYM	DFS	Tertile	All	1.000	0.662	.010	27	view →
SCLC	DFS	Median	All	0.368	0.559	.020	27	view →
KIRC	OS	Median	All	0.846	0.761	.002	25	view →
CHOL	DFS	Median	All	0.194	0.615	.007	20	view →
BRCA	OS	Median	II,III,IV	0.460	0.629	.019	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0070306–MESO (OS)

Open the MESO breakdown →