Protein poly-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein poly-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0232, SLCO2A1, and EIF4EBP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein poly-ADP-ribosylation activity versus KIAA0232 in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIAA0232 →	-0.475	-0.469	<.001	<.001	3	3
BRCA	SLCO2A1 →	-0.638	-0.548	.002	<.001	3	3
OV	EIF4EBP1 →	+0.725	+0.446	.001	.006	3	3
BRCA	DKK3 →	-0.756	-0.477	<.001	.002	3	3
HNSC	MID1IP1 →	-0.384	-0.218	.004	.001	3	2
HNSC	MIR641 →	-0.593	-0.201	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070212 vs KIAA0232 — BRCA

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