Protein poly-ADP-ribosylation

Across TCGA pan-cancer cohorts, RNA activity of the Protein poly-ADP-ribosylation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Protein poly-ADP-ribosylation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and BLCA, show the opposite pattern, with higher activity associated with better survival.

LGG, LAML, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.356	0.530	<.001	50	view →
LAML	DFS	Quartile	All	0.281	0.619	<.001	42	view →
LIHC	OS	Median	All	0.694	0.826	<.001	42	view →
UVM	DFS	Quartile	II,III,IV	0.284	0.687	.008	29	view →
READ	DFS	Quartile	All	0.734	0.273	.009	28	view →
BLCA	OS	Tertile	III,IV	0.660	0.291	.001	23	view →
STAD	DFS	Median	III,IV	0.387	0.581	.003	19	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	18	view →
SKCM	OS	Quartile	III,IV	0.913	0.716	.002	18	view →
CHOL	DFS	Tertile	III,IV	0.438	0.858	.024	15	view →
KICH	DFS	Quartile	II,III,IV	0.472	1.000	.006	13	view →
THCA	DFS	Quartile	IV	0.396	0.910	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0070212–LGG (OS)

Open the LGG breakdown →