Regulation of type B pancreatic cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of type B pancreatic cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP1, AOX1, and NID1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type B pancreatic cell proliferation activity versus SFRP1 in BRCA (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SFRP1 →	+0.802	+0.051	<.001	<.001	3	8
BRCA	AOX1 →	+0.602	+0.055	<.001	<.001	3	8
UCEC	NID1 →	+0.436	+0.060	.002	.003	3	7
UCEC	APBB1_T709 →	+0.729	+0.072	.004	.007	2	8
UCEC	ALDH1A1_T337 →	+0.830	+0.088	.001	<.001	3	6
LSCC	SYNPO2_S930 →	+0.956	+0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061469 vs SFRP1 — BRCA

Explore this scatter interactively →