Cell adhesion involved in heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, ZFPM2, and RAB33B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell adhesion involved in heart morphogenesis activity versus GASK1B in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GASK1B →	+0.602	+0.729	.002	<.001	3	4
HNSC	ZFPM2 →	+0.542	+0.737	.001	<.001	3	4
LUAD	RAB33B →	+0.360	+0.640	<.001	.001	3	4
HNSC	SLC2A10 →	+0.607	+0.739	<.001	<.001	3	4
LSCC	TWIST1 →	+0.750	+0.164	.004	.002	3	4
LSCC	ANXA5 →	+0.432	+0.219	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061343 vs GASK1B — HNSC

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