Cell adhesion involved in heart morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Cell adhesion involved in heart morphogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and ACC, show the opposite pattern, with higher activity associated with better survival.

SCLC, LGG, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	III,IV	0.784	0.315	.001	58	view →
LGG	DFS	Median	All	0.746	0.912	<.001	51	view →
LUSC	DFS	Median	III,IV	0.199	0.426	.011	29	view →
SKCM	DFS	Quartile	II,III,IV	0.130	0.439	.004	29	view →
ACC	DFS	Quartile	All	0.816	0.462	.002	28	view →
READ	OS	Tertile	II,III,IV	0.705	0.988	.005	22	view →
MESO	OS	Median	II,III,IV	0.731	0.315	.004	21	view →
SARC	DFS	Tertile	All	0.776	0.550	.002	17	view →
THYM	DFS	Tertile	All	0.974	0.849	.011	13	view →
LAML	DFS	Tertile	All	0.312	0.512	.040	12	view →
KIRP	DFS	Quartile	All	0.927	0.647	.014	11	view →
CESC	OS	Tertile	All	0.700	0.831	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0061343–SCLC (OS)

Open the SCLC breakdown →