Cell adhesion involved in heart morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and BRCA, show the opposite pattern, with lower activity in tumor tissue.

THCA, HNSC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	II,III,IV	+0.106	<.001	9	view →
HNSC	All	All	+0.044	<.001	8	view →
KIRP	All	All	+0.076	<.001	7	view →
LIHC	Male	All	+0.061	<.001	7	view →
KICH	All	All	+0.049	.001	5	view →
UCEC	All	All	−0.057	.005	4	view →
KIRC	Male	All	+0.037	<.001	4	view →
BRCA	All	All	−0.033	<.001	4	view →
CHOL	All	All	+0.104	<.001	3	view →
BLCA	All	IV	−0.072	.016	3	view →
COAD	Female	All	+0.060	.016	3	view →
PRAD	All	All	−0.023	.024	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0061343–THCA

Open the THCA breakdown →