Cell adhesion involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRM1, MAPK14, and MATN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRM1 grouped by Cell adhesion involved in heart morphogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRM1 →	+0.476	+0.766	.007	.006	3	4
LIVER	MAPK14 →	-0.880	-1.435	.008	.005	3	4
KIDNEY	MATN3 →	-2.725	-1.270	.001	.008	2	5
LUNG_NSCLC_LUSC	ANKRD13B →	+1.446	+1.224	.001	.003	3	4
SOFT_TISSUE	C15orf61 →	+0.684	+1.315	.002	.001	3	4
SOFT_TISSUE	RPL23A →	+0.638	+1.408	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRM1 by Cell adhesion involved in heart morphogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →