Regulation of mesonephros development

Across TCGA cell cohorts, RNA activity of the Regulation of mesonephros development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECTIN2, PRSS8, and NECTIN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECTIN2 grouped by Regulation of mesonephros development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NECTIN2 →	-0.235	-0.838	<.001	.002	3	4
BLOOD_Myeloma	PRSS8 →	-0.405	-1.696	.006	<.001	3	4
OVARY	NECTIN3 →	+0.205	+0.847	.003	.005	3	4
LARGE_INTESTINE	FABP1 →	-0.162	-1.017	.002	.002	3	4
SKIN	AGMO →	-0.158	-1.307	<.001	<.001	3	4
SKIN	PRAMEF14 →	+0.174	+0.797	.003	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECTIN2 by Regulation of mesonephros development activity — PANCREAS

Explore this box plot interactively →