Regulation of phospholipid catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP2K, SMARCE1, and AGO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid catabolic process activity versus BMP2K in OESOPHAGUS (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BMP2K →	-0.687	-1.549	.007	<.001	3	4
BLOOD_Leukemia	SMARCE1 →	-0.792	-1.463	<.001	<.001	3	4
OESOPHAGUS	AGO1 →	-0.871	-1.554	.001	.001	3	4
BREAST	TOX4 →	-0.678	-1.140	.004	.001	3	4
BLOOD_Lymphoma	CKAP2L →	-1.241	-1.127	.005	.001	3	4
BLOOD_Leukemia	KANSL3 →	-1.000	-1.654	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060696 vs BMP2K — OESOPHAGUS

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