Adipose tissue development

Across TCGA patient cohorts, RNA activity of the Adipose tissue development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPB1, THADA, and SDK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adipose tissue development activity versus SIRPB1 in UCEC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SIRPB1 →	-0.533	-0.134	.007	.009	3	3
UCEC	THADA →	+0.660	+0.190	.002	.002	3	3
UCEC	SDK1 →	+0.845	+0.172	.004	<.001	3	3
LUAD	PLEKHA8 →	+0.298	+0.103	.008	.006	3	3
LUAD	ZNF664 →	+0.358	+0.138	<.001	<.001	3	3
LUAD	MIR210HG →	-0.469	-0.145	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060612 vs SIRPB1 — UCEC

Explore this scatter interactively →