Regulation of DNA strand elongation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA strand elongation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, UPP1, and SAP30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA strand elongation activity versus ANKRD13B in BONE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANKRD13B →	+1.716	+0.331	.001	.001	3	7
BONE	UPP1 →	-2.528	-0.322	.002	.002	3	6
BLOOD_Lymphoma	SAP30 →	+0.898	+0.206	.002	<.001	3	5
OESOPHAGUS	STX2 →	+1.552	+0.340	.002	.003	3	5
BLOOD_Myeloma	UAP1L1 →	-1.754	-0.351	.005	.008	3	5
PANCREAS	IRF1 →	-1.547	-0.227	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060382 vs ANKRD13B — BONE

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