Micturition

Across TCGA cell cohorts, RNA activity of the Micturition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIPT2, RNF141, and NUDT16L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIPT2 grouped by Micturition-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LIPT2 →	-1.400	-1.862	.003	<.001	3	5
LUNG_NSCLC_LUAD	RNF141 →	-0.887	-1.003	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NUDT16L1 →	-0.994	-1.348	.006	.001	3	4
BLOOD_Myeloma	PEX2 →	-1.507	-1.769	.004	<.001	3	4
BONE	ADRA2C →	-2.846	-1.480	.002	.001	3	4
BREAST	CRY2 →	-0.959	-0.843	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIPT2 by Micturition activity — BLOOD_Lymphoma

Explore this box plot interactively →