Micturition

Across TCGA pan-cancer cohorts, RNA activity of the Micturition pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Micturition pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and LGG, show the opposite pattern, with higher activity associated with better survival.

LIHC, LGG, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	III,IV	0.787	0.457	.001	53	view →
LGG	DFS	Median	All	0.486	0.308	<.001	42	view →
ACC	DFS	Tertile	All	0.287	0.653	.002	39	view →
KIRC	OS	Tertile	All	0.711	0.501	<.001	34	view →
UVM	DFS	Tertile	III,IV	0.873	0.411	.003	29	view →
READ	OS	Tertile	II,III,IV	0.811	0.981	.004	22	view →
SKCM	OS	Tertile	III,IV	0.604	0.774	.004	20	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →
PRAD	OS	Tertile	All	1.000	0.820	.007	16	view →
SCLC	OS	Median	All	0.506	1.000	.004	14	view →
UCEC	DFS	Quartile	All	0.923	0.852	.013	14	view →
OV	DFS	Tertile	IV	0.562	0.261	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0060073–LIHC (OS)

Open the LIHC breakdown →