Acylglycerol homeostasis

Across TCGA cell cohorts, RNA activity of the Acylglycerol homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YARS1, WDR91, and ZADH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acylglycerol homeostasis activity versus YARS1 in OESOPHAGUS (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	YARS1 →	-1.021	-1.541	<.001	<.001	3	5
LUNG_NSCLC_LUSC	WDR91 →	-0.897	-1.519	.008	.002	3	5
SOFT_TISSUE	ZADH2 →	-1.103	-1.354	.002	.002	3	4
LIVER	SLAIN2 →	-1.080	-1.724	.006	<.001	3	4
CNS	PABPC1 →	-0.569	-0.837	.007	.009	3	4
BLOOD_Leukemia	VWA7 →	+0.470	+0.574	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055090 vs YARS1 — OESOPHAGUS

Explore this scatter interactively →