Cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, SYNPO2, and TNS2_S120, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell differentiation activity versus SYNPO in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO →	+0.594	+0.049	<.001	<.001	3	10
HNSC	SYNPO2 →	+0.918	+0.052	<.001	<.001	3	10
OV	TNS2_S120 →	+0.646	+0.028	<.001	<.001	3	10
UCEC	TPM1 →	+0.979	+0.060	<.001	<.001	3	10
LSCC	WDR36 →	-0.316	-0.033	<.001	<.001	3	10
UCEC	CAVIN2 →	+1.190	+0.063	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055007 vs SYNPO — UCEC

Explore this scatter interactively →