Cardiac muscle cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac muscle cell differentiation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 127 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Cardiac muscle cell differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and UVM, show the opposite pattern, with higher activity associated with better survival.

COAD, UCS, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Quartile	III,IV	0.448	0.773	<.001	64	view →
UCS	DFS	Quartile	III,IV	0.568	0.147	.006	36	view →
THCA	OS	Median	All	0.949	1.000	<.001	29	view →
UVM	OS	Tertile	II,III,IV	0.814	0.408	.004	28	view →
CESC	OS	Tertile	III,IV	0.168	0.676	.004	22	view →
LIHC	DFS	Tertile	All	0.360	0.513	.002	21	view →
SKCM	DFS	Median	All	0.658	0.554	.003	20	view →
ESCA	OS	Quartile	IV	0.206	0.916	.038	12	view →
KIRC	DFS	Tertile	IV	0.324	0.626	.023	12	view →
TGCT	DFS	Median	II,III,IV	0.732	1.000	.020	8	view →
GBM	DFS	Median	All	0.423	0.216	.013	6	view →
THYM	DFS	Quartile	III,IV	1.000	0.243	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0055007–COAD (OS)

Open the COAD breakdown →