Disruption of plasma membrane integrity in another organism

Across TCGA patient cohorts, RNA activity of the Disruption of plasma membrane integrity in another organism pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are H1-0, S100A12, and USP24_S2561, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disruption of plasma membrane integrity in another organism activity versus H1-0 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	H1-0 →	+0.805	+0.577	<.001	<.001	3	5
GBM	S100A12 →	+1.395	+0.546	<.001	<.001	3	4
GBM	USP24_S2561 →	-0.760	-0.487	<.001	.005	3	4
GBM	ANK1_S834 →	+0.941	+0.513	<.001	.004	3	4
GBM	MMP8 →	+1.491	+0.569	<.001	<.001	3	4
GBM	PADI4 →	+1.102	+0.539	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051673 vs H1-0 — GBM

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