Disruption of plasma membrane integrity in another organism

Across TCGA pan-cancer cohorts, RNA activity of the Disruption of plasma membrane integrity in another organism pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Disruption of plasma membrane integrity in another organism pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and UCEC, show the opposite pattern, with higher activity associated with better survival.

LGG, LUSC, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.534	0.348	<.001	48	view →
LUSC	OS	Tertile	All	0.672	0.822	<.001	45	view →
CESC	DFS	Tertile	IV	0.189	0.643	.007	36	view →
UCEC	DFS	Quartile	All	0.839	0.525	<.001	34	view →
SCLC	OS	Tertile	All	0.377	0.726	<.001	34	view →
SKCM	OS	Quartile	III,IV	0.422	0.854	.001	29	view →
UCS	OS	Tertile	All	0.173	0.558	.007	20	view →
PCPG	DFS	Median	All	0.822	0.940	.016	17	view →
ACC	DFS	Median	IV	0.160	0.490	.004	15	view →
THYM	OS	Median	All	1.000	0.921	.011	13	view →
KIRP	DFS	Median	IV	0.039	0.526	.016	12	view →
LAML	DFS	Median	All	0.282	0.495	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0051673–LGG (OS)

Open the LGG breakdown →