DEFA1B

Q-omics provides the consensus-scored DEFA1B profile across patient tissues and cancer cell-line models. DEFA1B expression is associated with patient survival in 1 of 34 cancer types, with the highest sampling consensus in GBM. Additionally, DEFA1B RNA expression shows 2 significant drug associations, with the highest sampling consensus in PEMB_ALL. Together, these results highlight GBM, and PEMB_ALL as cancer lineages where DEFA1B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes DEFA1B survival associations across molecular data types. DEFA1B RNA expression shows survival associations in the most cancer types (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFA1B data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	1	GBM (9)	view →

This table ranks reproducible DEFA1B RNA expression–survival associations across cancer types. High DEFA1B expression shows unfavorable associations in GBM. The GBM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .042). Together, the overview and detailed table identify GBM as the clearest survival context for DEFA1B RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.121	0.415	.042	9	view →

Pink = unfavorable, green = favorable. all 1 lineages →

DEFA1B-GBM (OS)

Explore this curve interactively →