DEFA1B

Across TCGA pan-cancer cohorts, DEFA1B RNA is linked to patient survival in 1 of 34 cancer types, making it the most broadly survival-associated DEFA1B data layer.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DEFA1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFA1B expression acts as an unfavorable survival marker.

GBM are the cancer types where DEFA1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.121	0.415	.042	9	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

DEFA1B–GBM (OS)

Open the GBM breakdown →