DEFA1B

Across TCGA cell cohorts, DEFA1B RNA expression is significantly associated with the mutation status of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEFA1B-associated genes across cancer lineages are PMPCA, BTRC, and KRCC1. Each is linked with DEFA1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA1B-to-partner and partner-to-DEFA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PMPCA grouped by DEFA1B-low versus DEFA1B-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA1B→partner) and Y-score (partner→DEFA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PMPCA →	+4.922	+3.829	.009	<.001	3	1
BLOOD_Leukemia	BTRC →	+4.922	+3.227	.009	<.001	3	1
BLOOD_Leukemia	KRCC1 →	+4.922	+3.829	.009	<.001	3	1
BLOOD_Leukemia	ZIC4 →	+4.922	+4.523	.009	<.001	3	1
BLOOD_Leukemia	PNMA8A →	+4.922	+2.098	.009	.003	3	1
BLOOD_Leukemia	GRID1 →	+4.922	+3.829	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PMPCA by DEFA1B expression — BLOOD_Leukemia

Explore this box plot interactively →