Disruption of plasma membrane integrity in another organism

Across TCGA cell cohorts, RNA activity of the Disruption of plasma membrane integrity in another organism pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEFA5, DEFA3, and FLVCR1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEFA5 grouped by Disruption of plasma membrane integrity in another organism-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DEFA5 →	-0.487	-1.727	.001	.005	3	10
KIDNEY	DEFA3 →	-0.216	-1.376	<.001	<.001	2	6
CNS	FLVCR1 →	+0.163	+0.773	.009	.001	3	5
LUNG_NSCLC_LUSC	TUBA1C →	+0.279	+1.052	.001	.005	3	3
SOFT_TISSUE	FLT3LG →	+0.185	+1.031	<.001	.004	3	3
SKIN	RNF112 →	-0.134	-0.756	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEFA5 by Disruption of plasma membrane integrity in another organism activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →