Disruption of plasma membrane integrity in another organism

Across TCGA cell cohorts, RNA activity of the Disruption of plasma membrane integrity in another organism pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEFA5, DEFA1, and MS4A3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disruption of plasma membrane integrity in another organism activity versus DEFA5 in LARGE_INTESTINE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA5 →	+1.600	+1.124	<.001	<.001	3	12
BLOOD_Leukemia	DEFA1 →	+2.421	+0.942	.003	<.001	3	11
BLOOD_Leukemia	MS4A3 →	+2.720	+0.669	<.001	<.001	3	8
BLOOD_Lymphoma	FBN1 →	-2.477	-0.208	<.001	.002	3	7
LARGE_INTESTINE	APOL2 →	-1.048	-1.160	.003	.001	3	7
BREAST	APOL1 →	-2.038	-0.184	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051673 vs DEFA5 — LARGE_INTESTINE

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