Nuclear pore localization

Across TCGA patient cohorts, RNA activity of the Nuclear pore localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RRM2, and SMC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore localization activity versus RFC2 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.463	+0.081	<.001	<.001	3	9
LUAD	RRM2 →	+0.873	+0.083	<.001	<.001	3	9
LUAD	SMC4 →	+0.614	+0.085	<.001	<.001	3	9
GBM	TIMELESS_S1173 →	+0.755	+0.111	<.001	<.001	3	9
LUAD	TOP2A →	+1.207	+0.096	<.001	<.001	3	9
LUAD	TOP2A_S1247 →	+1.584	+0.091	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051664 vs RFC2 — LSCC

Explore this scatter interactively →