Positive regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TANGO2, TMF1, and NEK7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-protein transferase activity activity versus TANGO2 in BONE (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TANGO2 →	-0.811	-0.122	.003	.009	3	4
LARGE_INTESTINE	TMF1 →	-0.921	-0.222	<.001	<.001	3	4
LARGE_INTESTINE	NEK7 →	-0.902	-0.169	<.001	<.001	3	4
KIDNEY	LDLRAP1 →	-1.433	-0.118	.007	.006	2	5
SOFT_TISSUE	IFIT1 →	-2.848	-0.164	.004	.007	3	3
SOFT_TISSUE	IFT80 →	+0.661	+0.163	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051443 vs TANGO2 — BONE

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