Regulation of ubiquitin-protein transferase activity

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin-protein transferase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPX2_S486, NCAPG, and SMC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-protein transferase activity activity versus TPX2_S486 in LUAD (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TPX2_S486 →	+1.120	+0.046	<.001	<.001	3	8
LUAD	NCAPG →	+0.846	+0.054	<.001	<.001	3	8
UCEC	SMC2 →	+0.699	+0.094	<.001	<.001	3	8
BRCA	SMC4 →	+0.650	+0.044	<.001	<.001	3	8
HNSC	TOP2A →	+0.851	+0.089	<.001	.001	3	8
UCEC	TPX2 →	+0.864	+0.074	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051438 vs TPX2_S486 — LUAD

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