Kinetochore organization

Across TCGA patient cohorts, RNA activity of the Kinetochore organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, TOP2A, and TOP2A_S1247, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kinetochore organization activity versus RPL12_S38 in LUAD (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.365	+0.179	<.001	<.001	3	10
LUAD	TOP2A →	+1.282	+0.194	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.636	+0.178	<.001	<.001	3	10
UCEC	RFC2 →	+0.416	+0.195	<.001	<.001	3	9
UCEC	RFC4 →	+0.402	+0.179	<.001	<.001	3	9
LSCC	RIF1 →	+0.413	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051383 vs RPL12_S38 — LUAD

Explore this scatter interactively →