Regulation of membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAL, C14orf28, and SNAI3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane protein ectodomain proteolysis activity versus ADAL in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAL →	+0.785	+0.898	<.001	.002	3	4
BLOOD_Leukemia	C14orf28 →	+0.550	+1.383	.001	<.001	3	4
BLOOD_Leukemia	SNAI3 →	-0.883	-0.673	.001	.006	3	4
STOMACH	NOP16 →	-0.740	-1.388	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NRARP →	-1.936	-1.278	.002	<.001	3	4
BLOOD_Leukemia	ZNF846 →	+0.849	+0.915	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051043 vs ADAL — BLOOD_Leukemia

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