Regulation of membrane protein ectodomain proteolysis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of membrane protein ectodomain proteolysis pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of membrane protein ectodomain proteolysis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ESCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.728	0.556	.003	86	view →
KIRC	DFS	Quartile	II,III,IV	0.415	0.703	.001	57	view →
LUSC	DFS	Quartile	All	0.690	0.807	<.001	43	view →
CESC	DFS	Tertile	All	0.638	0.825	.002	42	view →
ACC	DFS	Quartile	II,III,IV	0.095	0.755	.001	35	view →
COAD	DFS	Tertile	All	0.713	0.818	.007	22	view →
PCPG	DFS	Tertile	All	0.515	0.938	.006	15	view →
ESCA	OS	Median	III,IV	0.697	0.409	.001	15	view →
GBM	DFS	Tertile	All	0.152	0.330	.003	13	view →
SKCM	OS	Tertile	II,III,IV	0.426	0.232	.006	13	view →
DLBC	DFS	Median	II,III,IV	0.614	1.000	.021	11	view →
PRAD	DFS	Tertile	All	0.834	0.914	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0051043–HNSC (OS)

Open the HNSC breakdown →