Microtubule severing

Across TCGA patient cohorts, RNA activity of the Microtubule severing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNAP23_S20, SS18, and AKAP13_S2498, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule severing activity versus SNAP23_S20 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNAP23_S20 →	-0.457	-0.081	.008	.001	3	6
LSCC	SS18 →	+0.244	+0.064	<.001	<.001	3	5
LSCC	AKAP13_S2498 →	-0.436	-0.055	<.001	<.001	3	5
GBM	SLC16A3 →	-0.650	-0.066	.001	.001	3	5
HNSC	GRHPR →	+0.182	+0.038	.004	.004	3	5
OV	ME3 →	+0.395	+0.034	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051013 vs SNAP23_S20 — GBM

Explore this scatter interactively →