katanin catalytic subunit A1 like 2Genealiases: []
Q-omics provides the consensus-scored KATNAL2 profile across patient tissues and cancer cell-line models. KATNAL2 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, KATNAL2 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, KATNAL2 RNA expression shows 19,753 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and THCA as cancer lineages where KATNAL2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KATNAL2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KATNAL2 survival associations across molecular data types. KATNAL2 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KATNAL2 RNA expression–survival associations across cancer types. High KATNAL2 expression shows unfavorable associations in UVM, LGG and BLCA, but favorable associations in KIRP, PAAD and HNSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for KATNAL2 RNA expression.
This table summarizes KATNAL2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for KATNAL2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KATNAL2 shows lower tumor expression in THCA, KIRC, KIRP and COAD and higher tumor expression in KICH and LIHC. The THCA box plot shows higher KATNAL2 RNA expression in normal versus tumor tissue (log2 FC = −3.153, t-test p < 0.001).
This table shows molecular features associated with KATNAL2 in patient tissues and cancer cell lines. In patient samples, KATNAL2 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, KATNAL2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in CNS and BLOOD_Lymphoma.
