KATNAL2

Across TCGA patient cohorts, KATNAL2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KATNAL2-associated genes across cancer lineages are eEF2, MEK1, and PI3K-p110-a. Each is linked with KATNAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KATNAL2-to-partner and partner-to-KATNAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KATNAL2-low versus KATNAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNAL2→partner) and Y-score (partner→KATNAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.348	+2.115	.005	.016	3	2
UCEC	MEK1 →	+0.534	+2.874	<.001	<.001	3	2
UCEC	PI3K-p110-a →	-0.129	-1.807	.038	.025	3	2
UCEC	BRCA2 →	-0.100	-1.840	.032	.008	3	2
UCEC	14-3-3_beta →	-0.101	-2.673	.004	.005	3	1
UCEC	EGFR_pY1068 →	-0.232	-2.115	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by KATNAL2 expression — UCEC

Explore this box plot interactively →