Microtubule severing

Across TCGA patient cohorts, RNA activity of the Microtubule severing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFOD2, KIF3C, and UBXN2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule severing activity versus GFOD2 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GFOD2 →	+0.382	+0.660	.002	<.001	3	4
GBM	KIF3C →	+0.631	+0.523	<.001	<.001	3	4
GBM	UBXN2A →	+0.497	+0.630	<.001	<.001	3	4
CCRCC	PRR13 →	-0.363	-0.494	<.001	.003	3	3
BRCA	MEX3A →	+0.790	+0.599	.001	.002	3	3
CCRCC	FGF12 →	+0.316	+0.440	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051013 vs GFOD2 — GBM

Explore this scatter interactively →