Microtubule severing

Across TCGA cell cohorts, RNA activity of the Microtubule severing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A14, MANF, and TTYH3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule severing activity versus S100A14 in LUNG_NSCLC_LUSC (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	S100A14 →	+4.745	+0.411	.005	.003	3	4
PANCREAS	MANF →	-1.439	-0.276	.002	.007	3	3
PANCREAS	TTYH3 →	+1.380	+0.276	.006	.007	3	3
LUNG_NSCLC_LUSC	PKIA →	-2.513	-0.352	.001	.007	3	3
BREAST	CD101 →	+1.166	+0.089	<.001	.007	2	4
LUNG_SCLC	CBLC →	+1.422	+0.197	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051013 vs S100A14 — LUNG_NSCLC_LUSC

Explore this scatter interactively →