Sensory perception of light stimulus

Across TCGA patient cohorts, RNA activity of the Sensory perception of light stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, RFC4, and TK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of light stimulus activity versus TOP2A in HNSC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A →	-0.581	-0.130	<.001	<.001	3	6
GBM	RFC4 →	-0.410	-0.405	<.001	.001	3	5
HNSC	TK1 →	-0.705	-0.210	<.001	<.001	3	5
GBM	PRPF40A →	-0.338	-0.367	<.001	.001	2	6
BRCA	RSL1D1 →	-0.614	-0.171	<.001	<.001	3	4
BRCA	ASNS →	-0.821	-0.177	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050953 vs TOP2A — HNSC

Explore this scatter interactively →