Sensory perception of light stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Sensory perception of light stimulus pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 222 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Sensory perception of light stimulus pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, CHOL, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.817	0.328	.001	64	view →
CHOL	DFS	Median	II,III,IV	0.115	0.630	<.001	51	view →
HNSC	OS	Tertile	III,IV	0.256	0.489	.009	35	view →
LUAD	OS	Quartile	All	0.579	0.249	.008	27	view →
STAD	OS	Median	II,III,IV	0.508	0.613	.024	20	view →
DLBC	DFS	Tertile	All	0.455	1.000	.011	19	view →
KIRC	DFS	Quartile	III,IV	0.753	0.434	.016	17	view →
UCEC	DFS	Tertile	All	0.927	0.878	.027	16	view →
SCLC	DFS	Quartile	II,III,IV	0.144	0.509	.005	13	view →
LAML	DFS	Tertile	All	0.366	0.702	.002	12	view →
SKCM	OS	Median	IV	0.415	0.861	.014	12	view →
MESO	DFS	Quartile	All	0.839	0.362	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0050953–KIRP (OS)

Open the KIRP breakdown →