Brain morphogenesis

Across TCGA cell cohorts, RNA activity of the Brain morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC2, RSAD1, and PTRHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brain morphogenesis activity versus ATP5MC2 in BLOOD_Myeloma (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ATP5MC2 →	-0.929	-0.951	.001	.002	3	6
LUNG_NSCLC_LUAD	RSAD1 →	-0.812	-0.822	.001	.001	3	6
LUNG_NSCLC_LUAD	PTRHD1 →	-0.624	-0.709	.003	.003	3	6
LUNG_NSCLC_LUAD	FAM3C →	+1.448	+0.631	<.001	.007	2	7
OVARY	MYG1 →	-0.705	-0.833	<.001	.005	3	5
LUNG_NSCLC_LUAD	NECTIN4 →	+1.862	+0.631	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048854 vs ATP5MC2 — BLOOD_Myeloma

Explore this scatter interactively →