Brain morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Brain morphogenesis pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and KICH, show the opposite pattern, with lower activity in tumor tissue.

HNSC, COAD, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	IV	+0.059	<.001	12	view →
COAD	Female	All	+0.034	<.001	10	view →
LUSC	Male	All	+0.043	<.001	6	view →
READ	All	II,III,IV	+0.055	.020	4	view →
KIRC	All	II,III,IV	−0.013	.007	4	view →
BLCA	Female	All	+0.031	.037	2	view →
KICH	All	All	−0.031	.001	2	view →
STAD	All	IV	+0.030	.015	1	view →
LUAD	Male	All	+0.026	.022	1	view →
LIHC	Male	III,IV	−0.020	.010	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0048854–HNSC

Open the HNSC breakdown →