Pigment granule maturation

Across TCGA patient cohorts, RNA activity of the Pigment granule maturation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OMA1, GNL1, and PLOD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment granule maturation activity versus OMA1 in PDAC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OMA1 →	-0.520	-0.031	.005	.006	3	6
LSCC	GNL1 →	+0.163	+0.029	.004	.001	3	5
COAD	PLOD1 →	+0.292	+0.022	<.001	<.001	3	5
CCRCC	PXDN →	+0.381	+0.023	.002	.001	3	5
LSCC	SLC26A6 →	-0.328	-0.041	.005	.002	3	4
LSCC	SPCS3 →	-0.414	-0.038	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048757 vs OMA1 — PDAC

Explore this scatter interactively →