Pigment granule maturation

Across TCGA pan-cancer cohorts, RNA activity of the Pigment granule maturation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Pigment granule maturation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

STAD, HNSC, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	II,III,IV	0.479	0.817	<.001	60	view →
HNSC	OS	Median	IV	0.457	0.263	.010	44	view →
COAD	DFS	Tertile	III,IV	0.222	0.787	.004	42	view →
LIHC	DFS	Quartile	All	0.301	0.491	<.001	42	view →
UCS	DFS	Median	IV	0.996	0.522	.015	36	view →
READ	DFS	Median	II,III,IV	0.309	0.762	.004	27	view →
KIRP	OS	Tertile	All	0.576	0.831	.001	27	view →
UCEC	OS	Quartile	All	0.807	0.895	.014	24	view →
LGG	OS	Median	All	0.364	0.510	.005	13	view →
LUAD	OS	Median	II,III,IV	0.614	0.351	.010	13	view →
ACC	DFS	Tertile	All	0.290	0.744	<.001	12	view →
THCA	OS	Median	II,III,IV	1.000	0.696	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0048757–STAD (DFS)

Open the STAD breakdown →